Repairing tRNA termini: News from the 3' end
نویسندگان
چکیده
منابع مشابه
tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini.
The RNA ligase RtcB is conserved in all domains of life and is essential for tRNA maturation in archaea and metazoa. Here we show that bacterial and archaeal RtcB catalyze the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini. Reactions with analogues of RNA and GTP suggest a mechanism in which RtcB heals the 3'-phosphate terminus by forming a 2',3'-cyclic phosphate before...
متن کاملFrom End to End: tRNA Editing at 5'- and 3'-Terminal Positions
During maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities a...
متن کاملUnderstanding splicing from the 3′ end
Watching electrons lose steam in graphene Although graphene can be fabricated to be extremely clean, it still has a nonzero electrical resistance. Resistance is associated with turning electrons’ energy into heat, but how exactly does this happen? Halbertal et al. used a tiny scanning temperature probe based on a superconducting quantum interference device to investigate this problem. As the cu...
متن کاملDelivering messages from the 3' end.
R proteins perform many essential functions during basal gene expression and its regulation through their RNA-binding activity mediated by conserved domains (1, 2). The majority of these domains belong to a dozen or so RNA-binding motives that are now well characterized structurally and biochemically (3, 4). Their function is to target the protein to specific cellular RNAs: premRNAs, mature mRN...
متن کاملthe aesthetic dimension of howard barkers art: a frankfurtian approach to scenes from an execution and no end of blame
رابطه ی میانِ هنر و شرایطِ اجتماعیِ زایش آن همواره در طولِ تاریخ دغدغه ی ذهنی و دل مشغولیِ اساسیِ منتقدان و نیز هنرمندان بوده است. از آنجا که هنر در قفس آهنیِ زندگیِ اجتماعی محبوس است، گسترش وابستگیِ آن با نهاد ها و اصولِ اجتماعی پیرامون، صرفِ نظر از هم سو بودن و یا غیرِ هم سو بودنِ آن نهاد ها، امری اجتناب ناپذیر به نظر می رسد. با این وجود پدیدار گشتنِ چنین مباحثِ حائز اهمییتی در میان منتقدین، با ظهورِ مکتب ما...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA Biology
سال: 2016
ISSN: 1547-6286,1555-8584
DOI: 10.1080/15476286.2016.1239007